NON STEROIDAL ANTI INFLAMMATORY DRUGS AND ANTIPYRETICANALGESIC
NON STEROIDAL ANTI INFLAMMATORY DRUGS AND ANTIPYRETICANALGESIC INTRODUCTION • These drugs have analgesic , antipyretic and anti-inflammatory action. • Like morphine they do not depress CNS, do not produce physical dependence. • They act primarily on peripherally, but also in CNS to raise pain threshold. • They are also called nonopoidor nonnarcotic. C lassification 1. Non selective COX inhibitors a. Salicylate –aspirin, sodium salicylate b. Propionic acid derivatives –ibuprofen , naproxen c. Indole derivative –indomethacine, sulindac d. Pyrolo-pyrol derivative –ketorolac e. Pyrazolonederivative –phenylbutazone f. N-aryl anthranilic acid –mefenamic acid, meclofenamate, diclofenac g. Oxicam derivative –piroxicam 2 . PreferntialCOX-2 inhibitors – nimesulide, meloxicam 3. Selective COX-2 inhibitors – celecoxib, parecoxib 4 . Analgesic –antipyretic with poor anti inflammatory action a. Para aminophe...
